Anti-Met (c-Met) (phospho Y1356)抗体(ab73992)

概述

  • 产品名称Anti-Met (c-Met) (phospho Y1356)抗体
    参阅全部 Met (c-Met) 一抗
  • 描述
    兔多克隆抗体to Met (c-Met) (phospho Y1356)
  • 特异性ab73992 detects Met (c-Met) only when phosphorylated at tyrosine 1356.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Met (c-Met) around the phosphorylation site of tyrosine 1356 (A-T-YP-V-N).

  • 阳性对照
    • extracts from 3T3 cells

性能

应用

Our Abpromise guarantee covers the use of ab73992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 156 kDa (predicted molecular weight: 156 kDa).
ELISA 1/10000.

靶标

  • 功能Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
  • 疾病相关Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
    Note=Defects in MET may be associated with gastric cancer.
    Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].
    Defects in MET are a cause of renal cell carcinoma papillary (RCCP) [MIM:605074]. It is a subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into common renal cell carcinoma (clear cell, non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
    Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.
    Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 3 IPT/TIG domains.
    Contains 1 protein kinase domain.
    Contains 1 Sema domain.
  • 结构域The kinase domain is involved in SPSB1 binding.
  • 翻译后修饰Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AUTS9 antibody
    • c met antibody
    • D249 antibody
    • Hepatocyte growth factor receptor antibody
    • HGF antibody
    • HGF receptor antibody
    • HGF/SF receptor antibody
    • HGFR antibody
    • MET antibody
    • Met proto oncogene tyrosine kinase antibody
    • MET proto oncogene, receptor tyrosine kinase antibody
    • Met proto-oncogene (hepatocyte growth factor receptor) antibody
    • Met proto-oncogene antibody
    • Met protooncogene antibody
    • MET_HUMAN antibody
    • Oncogene MET antibody
    • Par4 antibody
    • Proto-oncogene c-Met antibody
    • RCCP2 antibody
    • Scatter factor receptor antibody
    • SF receptor antibody
    • Tyrosine-protein kinase Met antibody
    see all

Anti-Met (c-Met) (phospho Y1356) antibody 图像

  • All lanes : Anti-Met (c-Met) (phospho Y1356) antibody (ab73992) at 1/500 dilution

    Lane 1 : extracts from 3T3 cells
    Lane 2 : extracts from 3T3 cells with immunising phosphopeptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 156 kDa
    Observed band size : 156 kDa

Anti-Met (c-Met) (phospho Y1356) antibody (ab73992)参考文献

ab73992 has not yet been referenced specifically in any publications.

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