RabMAb

Anti-Mesothelin抗体[SP74] (ab93620)

概述

  • 产品名称Anti-Mesothelin抗体[SP74]
    参阅全部 Mesothelin 一抗
  • 描述
    兔单克隆抗体[SP74] to Mesothelin
  • 经测试应用适用于: IHC-P, Flow Cytmore details
  • 种属反应性
    与反应: Human
    预测可用于: Pig
  • 免疫原

    A synthetic peptide corresponding to C-terminus of human Mesothelin protein.

  • 阳性对照
    • Mesothelioma.

性能

应用

Our Abpromise guarantee covers the use of ab93620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt Use at an assay dependent concentration. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • 组织特异性Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • 疾病相关Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • 序列相似性Belongs to the mesothelin family.
  • 翻译后修饰Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • 细胞定位Secreted and Cell membrane. Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAK 1 antibody
    • CAK1 antibody
    • CAK1 antigen antibody
    • cleaved form antibody
    • Megakaryocyte potentiating factor antibody
    • Mesothelin antibody
    • Mesothelin isoform 1 precursor antibody
    • MPF antibody
    • Msln antibody
    • MSLN_HUMAN antibody
    • Pre pro megakaryocyte potentiating factor antibody
    • Pre-pro-megakaryocyte-potentiating factor antibody
    • SMR antibody
    • SMRP antibody
    • Soluble MPF mesothelin related protein antibody
    see all

Anti-Mesothelin antibody [SP74] 图像

  • Flow cytometric analysis of rabbit anti-Mesothelin (SP74) antibody ab93620(1/100) in HeLa cells (green) compared to negative control of rabbit IgG (blue).

  • Ab93620 (1:100) staining Mesothelin in human esothelioma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-Mesothelin antibody [SP74] (ab93620)参考文献

ab93620 has not yet been referenced specifically in any publications.

Product Wall


The peptide from mybiosource is a different peptide immunogen than the one used to produce our product ab93620. As I mentioned the exact immunogen sequence used to produce ab93620 is considered proprietary by our supplying lab however this peptide...

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Unfortunately, we do not have any purified mesothelin for sale. I suggest consulting www.biocompare.com. It is a search service that has access to the catalogues of many companies, one of which may have the purified protein you need.

The exact immunogen sequence is confidential. However I can say it is located within aa520-606 of Q13421 (Uniprot).

Thanks for your reply.
This antibody is raised against a small synthetic peptide of 15-20 amino acids.
I hope this is the information you were looking for. Please contact me again if you have any further questions.

Thank you for your enquiry but I don't quite understand what you are asking. Are you looking for a blocking peptide?
Thanks in advance for clarification!

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"