RabMAb

Anti-Mesothelin抗体[PPI-2e(IHC)] (ab92347)

概述

  • 产品名称
    Anti-Mesothelin抗体[PPI-2e(IHC)]
    参阅全部 Mesothelin 一抗
  • 描述
    兔单克隆抗体[PPI-2e(IHC)] to Mesothelin
  • 经测试应用
    适用于: WBmore details
    不适用于: IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues near the C terminus of Human Mesothelin.

  • 阳性对照
    • Fetal liver, uterus cancer, fetal pancreas and ovary cancer lysates.
  • 常规说明

    This antibody detects full-length Mesothelin precursor (69 kDa) and the C terminal cleaved form of Mesothelin.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab92347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 69 kDa.Can be blocked with Mesothelin peptide (ab134675).
  • 应用说明
    Is unsuitable for IHC-P or IP.
  • 靶标

    • 功能
      Membrane-anchored forms may play a role in cellular adhesion.
      Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
    • 组织特异性
      Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
    • 疾病相关
      Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
    • 序列相似性
      Belongs to the mesothelin family.
    • 翻译后修饰
      Both MPF and the cleaved form of mesothelin are N-glycosylated.
      Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
    • 细胞定位
      Secreted and Cell membrane. Golgi apparatus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CAK 1 antibody
      • CAK1 antibody
      • CAK1 antigen antibody
      • cleaved form antibody
      • Megakaryocyte potentiating factor antibody
      • Mesothelin antibody
      • Mesothelin isoform 1 precursor antibody
      • MPF antibody
      • Msln antibody
      • MSLN_HUMAN antibody
      • Pre pro megakaryocyte potentiating factor antibody
      • Pre-pro-megakaryocyte-potentiating factor antibody
      • SMR antibody
      • SMRP antibody
      • Soluble MPF mesothelin related protein antibody
      see all

    图片

    • All lanes : Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347) at 1/1000 dilution

      Lane 1 : Fetal liver lysate
      Lane 2 : Uterus cancer lysate
      Lane 3 : Fetal pancreas lysate
      Lane 4 : Ovary cancer lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit antibody at 1/2000 dilution

      Predicted band size : 69 kDa

    实验方案

    文献

    ab92347 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    I have good news today.

    We now added the blocking peptide for ab92347 to our catalog and it is available for purchase.

    ab134675

    http://www.abcam.com/index.html?datasheet=134675 (or use the following: http://www.abcam.com/i...

    Read More

    Thank you for your reply.

    I have to confirm that we do not have this peptide in our catalog at the moment. We are trying toadd this toour catalog but Ido not have any estimationwhen this will be available for your customer.

    Your cus...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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