概述

  • 产品名称Anti-MESDC2抗体
    参阅全部 MESDC2 一抗
  • 描述
    小鼠多克隆抗体to MESDC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human MESDC2 protein (NP_055969).

  • 阳性对照
    • MESDC2 transfected 293T cell lysate. Human liver tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab68809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).

靶标

  • 功能Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • 序列相似性Belongs to the MESD family.
  • 结构域The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • 细胞定位Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Anti-MESDC2 antibody 图像

  • Anti-MESDC2 antibody (ab68809) at 1/500 dilution + human liver lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 26 kDa
    Observed band size : 25 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MESDC2 antibody (ab68809) at 1/500 dilution

    Lane 1 : MESDC2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.

Anti-MESDC2 antibody (ab68809)参考文献

ab68809 has not yet been referenced specifically in any publications.

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