Anti-MERTK (phospho Y749 + Y753 + Y754)抗体(ab14921)


  • 产品名称
    Anti-MERTK (phospho Y749 + Y753 + Y754)抗体
    参阅全部 MERTK 一抗
  • 描述
    兔多克隆抗体to MERTK (phospho Y749 + Y753 + Y754)
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: CKKIYp SGDYpYpRQG, corresponding to amino acids 746-757 of Human MERTK.



Our Abpromise guarantee covers the use of ab14921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/750. Detects a band of approximately 180 kDa.


  • 功能
    In case of filovirus infection, seems to function as a cell entry factor.
  • 组织特异性
    Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • 疾病相关
    Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 细胞定位
  • Information by UniProt
  • 数据库链接
  • 别名
    • c MER antibody
    • c mer proto oncogene tyrosine kinase antibody
    • c-mer antibody
    • cMER antibody
    • cmer protooncogene tyrosine kinase antibody
    • Eyk antibody
    • MER antibody
    • MER receptor tyrosine kinase antibody
    • MERK antibody
    • MERPEN antibody
    • Mertk antibody
    • MERTK c-mer proto-oncogene tyrosine kinase antibody
    • MERTK_HUMAN antibody
    • MGC133349 antibody
    • nmf12 antibody
    • Nyk antibody
    • Proto oncogene tyrosine protein kinase MER antibody
    • Proto oncogene tyrosine protein kinase MER precursor antibody
    • Proto-oncogene c-Mer antibody
    • Receptor tyrosine kinase MerTK antibody
    • RP38 antibody
    • STK kinase antibody
    • Tyrosine-protein kinase Mer antibody
    see all


Anti-MERTK (phospho Y749 + Y753 + Y754) antibody (ab14921)参考文献

This product has been referenced in:
  • Kariolis MS  et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest 127:183-198 (2017). WB ; Human . Read more (PubMed: 27893463) »
  • Xie S  et al. Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib. Oncotarget 6:9206-19 (2015). WB ; Human . Read more (PubMed: 25826078) »

See all 3 Publications for this product

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The actual order number for ab14921 was 1197605. I have sent a new ab52968 with order number 1219455.

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I am sorry to hear that the results weren't improved. I am happy to replace the antibody with a new one however as this is the only phospho specific antibody we have so there in no option for replacement unless you wa...

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Thanks for the information.

The results are very strange. I am sorry I could not find a good reason why the antibodies are showing difference. Technically, they should show the same band size. The MERTK protein is heavily glycosylated so 180 k...

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Thank you for your email. I am sorry to hear that you have been experiencing problems with this antibody.

I have read the details you have kindly provided and would like to ask if you have repeated the experiment by changing any step in protoc...

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