Anti-MERTK抗体(ab70693)
Key features and details
- Rabbit polyclonal to MERTK
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-MERTK抗体
参阅全部 MERTK 一抗 -
描述
兔多克隆抗体to MERTK -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Chimpanzee, Rhesus monkey, Orangutan -
免疫原
Synthetic peptide corresponding to a region between residues 200 and 250 of human MERTK.
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阳性对照
- U937 cell whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab70693于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/5000 - 1/20000. Detects a band of approximately 120 kDa (predicted molecular weight: 110 kDa).
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说明 |
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WB
1/5000 - 1/20000. Detects a band of approximately 120 kDa (predicted molecular weight: 110 kDa). |
靶标
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功能
In case of filovirus infection, seems to function as a cell entry factor. -
组织特异性
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. -
疾病相关
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 10461 Human
- Entrez Gene: 17289 Mouse
- Omim: 604705 Human
- SwissProt: Q12866 Human
- SwissProt: Q60805 Mouse
- Unigene: 306178 Human
- Unigene: 239655 Mouse
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别名
- c MER antibody
- c mer proto oncogene tyrosine kinase antibody
- c-mer antibody
see all
图片
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Anti-MERTK antibody (ab70693) at 0.1 µg/ml + U937 cell lysate at 50 µg
Predicted band size: 110 kDa
Observed band size: 120 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab70693 被引用在 3 文献中.
- Chen CJ & Liu YP MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer. Pharmaceuticals (Basel) 14:N/A (2021). PubMed: 33562150
- Zheng G et al. MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells. Emerg Microbes Infect 9:571-581 (2020). PubMed: 32172658
- Jiang J et al. Crucial roles for protein kinase C isoforms in tumor-specific killing by apoptin. Cancer Res 70:7242-52 (2010). WB ; Human . PubMed: 20719884