概述

  • 产品名称Anti-MER + SKY抗体
  • 描述
    兔多克隆抗体to MER + SKY
  • 特异性Detects endogenous levels of total MER + SKY protein.
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human MER + SKY around the phosphorylation site of tyrosine 749/681 (K-I-YP-S-G).

  • 阳性对照
    • WB: extracts from 3T3 cells treated with EGF (200ng/ml, 5mins); IHC-P: Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab79223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
IHC-P
  • 应用说明ELISA: 1/5000.
    IHC-P: 1/50 - 1/100.
    WB: 1/500 - 1/1000. Predicted molecular weight: 110 or 97 kDa (MER and SKY respectively).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性MER is a member of the MER/AXL/SKY receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). SKY may be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.
    • 细胞定位Membrane; Single-pass type I membrane protein
    • 数据库链接
    • 别名
      • AI323366 antibody
      • Brt antibody
      • Bruton agammaglobulinemia tyrosine kinase antibody
      • BYK antibody
      • c-mer antibody
      • c-mer proto-oncogene tyrosine kinase antibody
      • Dtk antibody
      • Etk 2 antibody
      • Eyk antibody
      • FLJ16467 antibody
      • Mer antibody
      • MER receptor tyrosine kinase antibody
      • MERTK antibody
      • MGC133349 antibody
      • Nyk antibody
      • OTTMUSP00000017810 antibody
      • rdy antibody
      • Receptor tyrosine kinase antibody
      • Receptor tyrosine kinase MerTK antibody
      • Receptor tyrosine tinase gene probably the gene for Rdy antibody
      • Retinal dystrophy antibody
      • RP23-30M20.1 antibody
      • RP23-356L21.1 antibody
      • RP38 antibody
      • RSE antibody
      • Sky antibody
      • STK kinase antibody
      • Tif antibody
      • TYRO3 antibody
      • TYRO3 protein tyrosine kinase 3 antibody
      • TYRO3 protein tyrosine kinase antibody
      • Tyrosine protein kinase byk antibody
      • Tyrosine protein kinase DTK antibody
      • Tyrosine protein kinase RSE antibody
      • Tyrosine protein kinase SKY antibody
      see all

    Anti-MER + SKY antibody 图像

    • Left panel: immunohistochemistry analysis of paraffin-embedded Human brain tissue using 1/50 ab79223. Right panel: same, after pre-incubation with the immunizing peptide.
    • All lanes : Anti-MER + SKY antibody (ab79223) at 1/500 dilution

      Lane 1 : 3T3 cell extract treated with EGF (200ng/ml, 5mins)
      Lane 2 : 3T3 cell extract treated with EGF (200ng/ml, 5mins) with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 110 , 97 kDa
      Observed band size : 97 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 120 kDa,150 kDa. We are unsure as to the identity of these extra bands.

    Anti-MER + SKY antibody (ab79223)参考文献

    ab79223 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab79223.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"