Anti-Menin抗体(Agarose) (ab19206)


  • 产品名称Anti-Menin抗体(Agarose)
    参阅全部 Menin 一抗
  • 描述
    兔多克隆抗体to Menin (Agarose)
  • 偶联物Agarose
  • 经测试应用适用于: IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide (Human) (C terminal).

  • 常规说明Affinity purified antibodies were coupled to agarose beads using a cyanogen bromide method. 100ug of antibody is provided in 200ul of agarose which is in a 400ul volume leading to a final concentration of 0.25 ug/ul in 400ul volume.



Our Abpromise guarantee covers the use of ab19206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明IP: 15 to 25ul of gel slurry per 0.1 to 1 mg of protein lysate or extract.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
    • 组织特异性Ubiquitous.
    • 疾病相关Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]. Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
      Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MEA 1 antibody
      • MEA1 antibody
      • MEN 1 antibody
      • Men1 antibody
      • MEN1_HUMAN antibody
      • Menin antibody
      • Multiple Endocrine Adenomatosis 1 antibody
      • Multiple Endocrine Neoplasia 1 antibody
      • SCG 2 antibody
      • SCG2 antibody
      • Suppressor Candidate Gene 2 antibody
      • Wermer syndrome antibody
      • ZES antibody
      • Zollinger Ellison Syndrome antibody
      see all

    Anti-Menin antibody (Agarose) (ab19206)参考文献

    ab19206 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab19206.
    Please use the links above to contact us or submit feedback about this product.