Anti-Melatonin Receptor 1A/MTNR1A抗体(ab87639)
Key features and details
- Goat polyclonal to Melatonin Receptor 1A/MTNR1A
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Melatonin Receptor 1A/MTNR1A抗体
参阅全部 Melatonin Receptor 1A/MTNR1A 一抗 -
描述
山羊多克隆抗体to Melatonin Receptor 1A/MTNR1A -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human Melatonin Receptor 1A/MTNR1A aa 132-144 (internal sequence) (Cysteine residue).
Sequence:SLKYDKLYSSKNS
Database link: NP_005949.1 -
阳性对照
- KELLY lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab87639于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 39 kDa).
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 39 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. -
组织特异性
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 4543 Human
- Omim: 600665 Human
- SwissProt: P48039 Human
- Unigene: 243467 Human
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别名
- Mel 1A R antibody
- MEL-1A-R antibody
- Mel1a melatonin receptor antibody
see all
图片
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Anti-Melatonin Receptor 1A/MTNR1A antibody (ab87639) at 0.3 µg/ml + KELLY lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 39 kDa
Observed band size: 45 kDa why is the actual band size different from the predicted?
Exposure time: 1 hour
数据表及文件
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SDS download
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Datasheet download
文献 (10)
ab87639 被引用在 10 文献中.
- Park H & Kim J Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model. J Pineal Res 72:e12787 (2022). PubMed: 35133672
- Lutfi E et al. The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comp Biochem Physiol B Biochem Mol Biol 256:110634 (2021). PubMed: 34119649
- Elmi A et al. Testicular Melatonin and Its Pathway in Roe Deer Bucks (Capreolus capreolus) during Pre- and Post-Rut Periods: Correlation with Testicular Involution. Animals (Basel) 11:N/A (2021). PubMed: 34201764
- Yi G et al. A study of the mechanism of small-molecule soybean-protein-derived peptide supplement to promote sleep in a mouse model. RSC Adv 10:11264-11273 (2020). PubMed: 35495343
- Wang Z et al. Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria. Front Physiol 11:408 (2020). PubMed: 32435203
- Dong K et al. Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage. Int J Mol Sci 21:N/A (2020). PubMed: 31947744
- Xiang S et al. Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. J Pineal Res 67:e12586 (2019). PubMed: 31077613
- Villarreal MA et al. Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Zebrafish 14:387-389 (2017). PubMed: 28318435
- Mori F et al. Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget 7:20532-48 (2016). WB . PubMed: 26967561
- Santoro R et al. Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation. Carcinogenesis : (2013). PubMed: 23354312