概述

  • 产品名称Anti-Melanophilin抗体
    参阅全部 Melanophilin 一抗
  • 描述
    兔多克隆抗体to Melanophilin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 540-569 of Human Melanophilin (NP_001035932.1 , NP_077006.1).

  • 阳性对照
    • A375 cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab112954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 66 kDa.

靶标

  • 功能Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
  • 疾病相关Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations.
  • 序列相似性Contains 1 FYVE-type zinc finger.
    Contains 1 RabBD (Rab-binding) domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2210418F23Rik antibody
    • 5031433I09Rik antibody
    • AW228792 antibody
    • D1Wsu84e antibody
    • Exophilin 3 antibody
    • Exophilin-3 antibody
    • l(1)-3Rk antibody
    • l1Rk3 antibody
    • Leaden antibody
    • Leaden protein antibody
    • ln antibody
    • Melanophilin antibody
    • MELPH_HUMAN antibody
    • MGC2771 antibody
    • MGC59733 antibody
    • Mlph antibody
    • Slac 2a antibody
    • SlaC2-a antibody
    • Slp homolog lacking C2 domains a antibody
    • Synaptotagmin like protein 2a antibody
    • Synaptotagmin like protein lacking C2 domains A antibody
    • Synaptotagmin-like protein 2a antibody
    see all

Anti-Melanophilin antibody 图像

  • Anti-Melanophilin antibody (ab112954) at 1/100 dilution + A375 cell line lysate at 35 µg

    Predicted band size : 66 kDa

Anti-Melanophilin antibody (ab112954)参考文献

This product has been referenced in:
  • Cetica V  et al. Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding. J Allergy Clin Immunol 135:1310-1318.e1 (2015). Read more (PubMed: 25312756) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab112954.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"