概述

  • 产品名称Anti-MEK3抗体
    参阅全部 MEK3 一抗
  • 描述
    兔多克隆抗体to MEK3
  • 特异性No cross reactivity with other proteins.
  • 经测试应用适用于: WB, IHC-P, ICCmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide:

    MEHPFFTLHKTKKTD

    , corresponding to C terminal amino acids 320-334 of Human MEK3.

  • 阳性对照
    • Rat spleen tissue lysate, Rat thymus tissue lysate, Rat skeletal muscle tissue lysate, Rat kidney tissue lysate, MCF-7 whole cell lysate, HeLa whole cell lysate, Raji whole cell lysate, CEM whole cell lysate, Colo320 whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab109557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC Use a concentration of 1 µg/ml.

靶标

  • 功能Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
  • 组织特异性Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 疾病相关Note=Defects in MAP2K3 may be involved in colon cancer.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
    Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AW212142 antibody
    • dual specificity mitogen activated protein kinase kinase 3 antibody
    • Dual specificity mitogen-activated protein kinase kinase 3 antibody
    • MAP kinase kinase 3 antibody
    • map2k3 antibody
    • MAPK ERK kinase 3 antibody
    • MAPK/ERK kinase 3 antibody
    • MAPKK 3 antibody
    • MAPKK3 antibody
    • MEK 3 antibody
    • MEK3 antibody
    • Mitogen activated protein kinase kinase 3 antibody
    • MKK 3 antibody
    • MKK3 antibody
    • mMKK3b antibody
    • MP2K3_HUMAN antibody
    • PRKMK 3 antibody
    • PRKMK3 antibody
    • protein kinase, mitogen-activated, kinase 3 antibody
    • SAPK kinase 2 antibody
    • SAPKK 2 antibody
    • SAPKK2 antibody
    • Stress activated protein kinase kinase 2 antibody
    see all

Anti-MEK3 antibody 图像

  • All lanes : Anti-MEK3 antibody (ab109557) at 1 µg/ml

    Lane 1 : Rat spleen tissue lysate
    Lane 2 : Rat thymus tissue lysate
    Lane 3 : Rat skeletal muscle tissue lysate
    Lane 4 : Rat kidney tissue lysate
    Lane 5 : MCF-7 whole cell lysate
    Lane 6 : HeLa whole cell lysate
    Lane 7 : Raji whole cell lysate
    Lane 8 : CEM whole cell lysate
    Lane 9 : Colo320 whole cell lysate


    Predicted band size : 39 kDa

Anti-MEK3 antibody (ab109557)参考文献

ab109557 has not yet been referenced specifically in any publications.

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