Anti-MEIS1抗体[EPR5781] (ab124686)


  • 产品名称Anti-MEIS1抗体[EPR5781]
    参阅全部 MEIS1 一抗
  • 描述
    兔单克隆抗体[EPR5781] to MEIS1
  • 特异性The immunogen of ab124686 is, according to BLAST results, conserved (57%) with human MEIS2. According to this, the antibody might cross-react with MEIS2 but this has, to our knowledge, not been experimentally tested so far.
  • 经测试应用适用于: WB, IP, Flow Cytmore details
    不适用于: ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, corresponding to a sequence within Human MEIS1.

  • 阳性对照
    • U-87 MG, K562, and HeLa cell lysates; permeabilized K562 cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124686 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 47 kDa (predicted molecular weight: 43 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC or IHC-P.
  • 靶标

    • 功能Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
    • 组织特异性Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
    • 疾病相关Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
    • 序列相似性Belongs to the TALE/MEIS homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Homeo box protein Meis1 antibody
      • Homeobox protein Meis1 antibody
      • Leukemogenic homolog protein antibody
      • MEIS 1 antibody
      • Meis homeo box 1 antibody
      • Meis homeobox 1 antibody
      • Meis1 antibody
      • Meis1 mouse homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
      • MEIS1 protein antibody
      • MEIS1_HUMAN antibody
      • MGC43380 antibody
      • Myeloid ecotropic viral integration site 1 homolog antibody
      • WUGSC:H NH0444B04.1 antibody
      see all

    Anti-MEIS1 antibody [EPR5781] 图像

    • All lanes : Anti-MEIS1 antibody [EPR5781] (ab124686) at 1/10000 dilution

      Lane 1 : U-87 MG cell lysate
      Lane 2 : K562 cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size : 43 kDa
      Observed band size : 47 kDa (why is the actual band size different from the predicted?)
    • ab124686 at 1/10 dilution staining MEIS1 in permeabilized K562 by Flow cytometry (red). Rabbit IgG negative control (green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-MEIS1 antibody [EPR5781] (ab124686)参考文献

    ab124686 has not yet been referenced specifically in any publications.

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