概述

  • 产品名称Anti-MEIS1抗体
    参阅全部 MEIS1 一抗
  • 描述
    山羊多克隆抗体to MEIS1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    C-SEDITRSANLTDQ

    , corresponding to internal sequence amino acids 198 - 210 of Human MEIS1 (NP_002389.1)

  • 阳性对照
    • Human Cerebral Cortex lysate

性能

应用

Our Abpromise guarantee covers the use of ab80593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: antibody detection limit dilution 1/32000
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 43 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
    • 组织特异性Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
    • 疾病相关Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
    • 序列相似性Belongs to the TALE/MEIS homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Homeo box protein Meis1 antibody
      • Homeobox protein Meis1 antibody
      • Leukemogenic homolog protein antibody
      • MEIS 1 antibody
      • Meis homeo box 1 antibody
      • Meis homeobox 1 antibody
      • Meis1 antibody
      • Meis1 mouse homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
      • MEIS1 protein antibody
      • MEIS1_HUMAN antibody
      • MGC43380 antibody
      • Myeloid ecotropic viral integration site 1 homolog antibody
      • WUGSC:H NH0444B04.1 antibody
      see all

    Anti-MEIS1 antibody 图像

    • Anti-MEIS1 antibody (ab80593) at 0.1 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg

      Predicted band size : 43 kDa
      Observed band size : 43 kDa

    Anti-MEIS1 antibody (ab80593)参考文献

    ab80593 has not yet been referenced specifically in any publications.

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