概述

  • 产品名称
  • 描述
    兔多克隆抗体to MEF2B
  • 经测试应用
    适用于: WB, EMSA, IPmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 234-365 of Human MEF2B

性能

应用

Our Abpromise guarantee covers the use of ab33540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 39 kDa.
EMSA Use at an assay dependent dilution. Use 0.1µl per sample.
IP Use at an assay dependent dilution. Use 4µl for 1ml cell lysate.

靶标

  • 功能
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
  • 组织特异性
    Expressed in skeletal and cardiac muscle and brain.
  • 序列相似性
    Belongs to the MEF2 family.
    Contains 1 MADS-box domain.
    Contains 1 Mef2-type DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MADS box transcription enhancer factor 2 antibody
    • MDS1 EVI1 antibody
    • Mef2b antibody
    • MEF2B_HUMAN antibody
    • Myocyte enhancer factor 2B antibody
    • Myocyte specific enhancer factor 2B antibody
    • Myocyte-specific enhancer factor 2B antibody
    • PRDM3 antibody
    • RSRFR2 antibody
    • Serum response factor like protein 2 antibody
    • Serum response factor-like protein 2 antibody
    • XMEF2 antibody
    see all

文献

This product has been referenced in:
  • Pon JR  et al. MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nat Commun 6:7953 (2015). IP ; Human . Read more (PubMed: 26245647) »
  • Ryan RJ  et al. Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma. Cancer Discov 5:1058-71 (2015). Read more (PubMed: 26229090) »

See all 7 Publications for this product

客户评价及客户问答

The immunogen of ab33540 derives from the protein MEF2B isoform b, http://www.ncbi.nlm.nih.gov/protein/5174543. It is originally from the gene RSRFR2 described in Pollack and Treisman, Genes and Development 1991.

The immunogen sequence is aa 2...

Read More

Muchas gracias por tomarte la molestia de mandarnos el cuestionario y las imágenes.

He estudiado el protocolo enviado, y hay una serie de sugerencias que me gustaría haceros para intentar mejorar los resultados del anticuerpo. <...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册