概述

性能

应用

Our Abpromise guarantee covers the use of ab57703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the Mediator complex subunit 8 family.
    • 结构域The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activator recruited cofactor 32 kDa component antibody
      • Activator-recruited cofactor 32 kDa component antibody
      • ARC32 antibody
      • med8 antibody
      • MED8_HUMAN antibody
      • Mediator complex subunit 8 antibody
      • Mediator of RNA polymerase II transcription subunit 8 antibody
      • Mediator of RNA polymerase II transcription subunit 8 homolog antibody
      see all

    Anti-MED8 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57703 MED8 antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa

    Anti-MED8 antibody (ab57703)参考文献

    ab57703 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"