概述

  • 产品名称Anti-MED12抗体
    参阅全部 MED12 一抗
  • 描述
    兔多克隆抗体to MED12
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within the C terminal amino acids 2150-2212 of Human MED12, NP_005111.1

  • 阳性对照
    • Human breast adenocarcinoma. Mouse squamous cell carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
    • 组织特异性Ubiquitous.
    • 疾病相关Defects in MED12 are the cause of Opitz-Kaveggia syndrome (OKS) [MIM:305450]; also known as FG syndrome type 1 (FGS1) or FG syndrome (FGS). OKS is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
      Defects in MED12 are the cause of Lujan-Fryns syndrome (LUJFRYS) [MIM:309520]; also known as X-linked mental retardation with marfanoid habitus. Clinically, Lujan-Fryns syndrome can be distinguished from Opitz-Kaveggia syndrome by tall stature, hypernasal voice, hyperextensible digits and high nasal root.
    • 序列相似性Belongs to the Mediator complex subunit 12 family.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activator recruited cofactor 240 kDa component antibody
      • Activator-recruited cofactor 240 kDa component antibody
      • ARC240 antibody
      • CAG repeat protein 45 antibody
      • CAGH45 antibody
      • HOPA antibody
      • KIAA0192 antibody
      • MED12 antibody
      • MED12_HUMAN antibody
      • Mediator complex subunit 12 antibody
      • Mediator of RNA polymerase II transcription subunit 12 antibody
      • OPA containing protein antibody
      • OPA-containing protein antibody
      • Thyroid hormone receptor associated protein complex 230 kDa component antibody
      • Thyroid hormone receptor-associated protein complex 230 kDa component antibody
      • TNRC11 antibody
      • Trap230 antibody
      • Trinucleotide repeat containing gene 11 protein antibody
      • Trinucleotide repeat-containing gene 11 protein antibody
      see all

    Anti-MED12 antibody 图像

    • Detection of Human MED12 by Immunohistochemistry.
      Sample: FFPE section of Human breast adenocarcinoma.
      Antibody: ab84430 used at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Mouse MED12 by Immunohistochemistry.
      Sample: FFPE section of Mouse squamous cell carcinoma.
      Antibody: ab84430 used at a dilution of 1/250.
      Detection: DAB staining.

    Anti-MED12 antibody (ab84430)参考文献

    ab84430 has not yet been referenced specifically in any publications.

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