Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 µM, 3.6 µM and 6.9 µM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM and in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Rabenstein RL et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl)189:395-401 (2006).
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Papke RL et al. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther297:646-56 (2001).
Read more (PubMed: 11303054) »