Mdivi-1,Drp1抑制剂(ab144589)
Key features and details
- Selective, cell-permeable mitochondrial division Drp1 inhibitor
- CAS Number: 338967-87-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Mdivi-1,Drp1抑制剂 -
描述
Selective,cell-permeable mitochondrial division Drp1抑制剂 -
纯度
> 98% -
CAS编号
338967-87-6 -
化学结构
性能
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化学名称
3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone -
分子量
353.23 -
分子式
C15H10Cl2N2O2S -
PubChem识别号
3825829 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab144589 被引用在 12 文献中.
- Pan J et al. Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface. J Pharmacol Exp Ther 388:506-517 (2024). PubMed: 37442618
- Liu S et al. Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. FASEB J 37:e22852 (2023). PubMed: 36906289
- Ji Y et al. The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy in type 2 diabetic rats. Cell Stress Chaperones 27:353-367 (2022). PubMed: 35426609
- Luo J et al. Microsporidia Promote Host Mitochondrial Fragmentation by Modulating DRP1 Phosphorylation. Int J Mol Sci 23:N/A (2022). PubMed: 35887094
- Weindel CG et al. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell 185:3214-3231.e23 (2022). PubMed: 35907404