Anti-mMCP-4抗体(ab92368)
Key features and details
- Goat polyclonal to mMCP-4
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-mMCP-4抗体 -
描述
山羊多克隆抗体to mMCP-4 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide corresponding to Mouse mMCP-4 aa 114-126 (internal sequence) (Cysteine residue).
Sequence:KLQKKAKETPSVN
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab92368 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab92368于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-
-Ile-5' bond of angiotensin I and the 'Phe-20-
-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-
-His-9' bond of angiotensin I and the 'Phe-4-
-Ala-5' and 'Tyr-10-
-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. -
组织特异性
Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. -
序列相似性
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. - Information by UniProt
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数据库链接
- Entrez Gene: 17227 Mouse
- SwissProt: P21812 Mouse
- Unigene: 439684 Mouse
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别名
- Mast cell protease 4 antibody
- Mcp 4 antibody
- Mcpt4 antibody
see all
数据表及文件
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Datasheet download
文献 (3)
ab92368 被引用在 3 文献中.
- Terai K et al. Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Int J Mol Sci 21:N/A (2020). PubMed: 33050674
- Mackey E et al. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood. Proc Natl Acad Sci U S A 117:23751-23761 (2020). PubMed: 32917815
- Rowbotham SP et al. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nat Commun 9:4559 (2018). PubMed: 30455465