概述

  • 产品名称Anti-MCP4抗体
    参阅全部 MCP4 一抗
  • 描述
    兔多克隆抗体to MCP4
  • 经测试应用适用于: Indirect ELISA, Sandwich ELISA, Neutralising, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Highly pure (>98%) recombinant Human MCP4

性能

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应用

Our Abpromise guarantee covers the use of ab110609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Indirect ELISA Use a concentration of 0.5 - 2 µg/ml. (using 100 µl/well antibody solution) allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human MCP4.
Sandwich ELISA Use a concentration of 0.5 - 2 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to MCP4 (Biotin) (ab83122). Using ab83122 as the detection antibody and ab110609 as the capture antibody, the detection limit for recombinant Human MCP4 is 0.2 - 0.4 ng/well, using 100 µl/well antibody solution.
Neutralising Use a concentration of 1 - 1.5 µg/ml. to yield one-half maximal inhibition [ND50] of the biological activity of MCP4 (30.0 ng/ml)
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 11 kDa. The detection limit for recombinant Human MCP4 is 3.0 - 4.0 ng/lane, under either reducing or non-reducing conditions.

靶标

  • 功能Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
  • 组织特异性Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
  • 序列相似性Belongs to the intercrine beta (chemokine CC) family.
  • 翻译后修饰One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C-C motif chemokine 13 antibody
    • CCL13 antibody
    • CCL13_HUMAN antibody
    • Chemokine (C C motif) ligand 13 antibody
    • CK beta 10 antibody
    • CK-beta-10 antibody
    • CKb10 antibody
    • MCP-4 antibody
    • MGC17134 antibody
    • Monocyte chemoattractant protein 4 antibody
    • Monocyte chemotactic protein 4 antibody
    • NCC 1 antibody
    • NCC-1 antibody
    • NCC1 antibody
    • New CC chemokine 1 antibody
    • SCYA13 antibody
    • SCYL1 antibody
    • short chain antibody
    • Small inducible cytokine A13 precursor antibody
    • Small inducible cytokine subfamily A (Cys Cys) member 13 antibody
    • Small-inducible cytokine A13 antibody
    see all

Anti-MCP4 antibody (ab110609)参考文献

ab110609 has not yet been referenced specifically in any publications.

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