Anti-MCP1抗体(ab9899)
Key features and details
- Rabbit polyclonal to MCP1
- Suitable for: Sandwich ELISA
- Isotype: unknown
概述
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产品名称
Anti-MCP1抗体
参阅全部 MCP1 一抗 -
描述
兔多克隆抗体to MCP1 -
宿主
Rabbit -
经测试应用
适用于: Sandwich ELISAmore details -
免疫原
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常规说明
JE, also known as monocyte chemotactic protein (MCP-1), plays an important role in the inflammatory response of blood monocytes and tissue macrophages
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute with 200µl of sterile water. -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
No preservative, sterile filtered -
Concentration information loading...
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纯度
Immunogen affinity purified -
Primary antibody说明
JE, also known as monocyte chemotactic protein (MCP-1), plays an important role in the inflammatory response of blood monocytes and tissue macrophages -
克隆
多克隆 -
同种型
unknown -
轻链类型
unknown -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
应用
应用 | Ab评论 | 说明 |
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Sandwich ELISA |
Use at an assay dependent concentration.
To detect MCP-1 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Murine MCP-1 (500-P113Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant MCP-1. |
说明 |
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Sandwich ELISA
Use at an assay dependent concentration. To detect MCP-1 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Murine MCP-1 (500-P113Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant MCP-1. |
靶标
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功能
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. -
序列相似性
Belongs to the intercrine beta (chemokine CC) family. -
翻译后修饰
Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. -
细胞定位
Secreted. - Information by UniProt
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别名
- C-C motif chemokine 2 antibody
- CCL2 antibody
- CCL2_HUMAN antibody
see all
数据表及文件
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Datasheet download
文献 (6)
ab9899 被引用在 6 文献中.
- Shi X et al. Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal. BMC Neurosci 23:20 (2022). PubMed: 35354428
- Xu SB et al. Peptide 17 alleviates early hypertensive renal injury by regulating the Hippo/YAP signalling pathway. Nephrology (Carlton) 27:712-723 (2022). PubMed: 35608936
- Huang T et al. Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer. Front Oncol 10:19 (2020). PubMed: 32064233
- Feng Y et al. Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease. Cell Death Dis 11:513 (2020). PubMed: 32641688
- Lv J et al. Amygdalin ameliorates the progression of atherosclerosis in LDL receptor-deficient mice. Mol Med Rep 16:8171-8179 (2017). PubMed: 28983592
- Zhang L et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 527:100-104 (2015). PubMed: 26479035