概述

  • 产品名称Anti-MCM8抗体
    参阅全部 MCM8 一抗
  • 描述
    小鼠单克隆抗体to MCM8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: TYSDEFGNLD FERSQHGSGM SNRSTAKRFI SALNNVAERT YNNIFQFHQL RQIAKELNIQ VADFENFIGS LNDQGYLLKK GPKVYQLQTM , corresponding to amino acids 646-735 of Human MCM8

性能

应用

Our Abpromise guarantee covers the use of ab57829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
    • 组织特异性Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
    • 序列相似性Belongs to the MCM family.
      Contains 1 MCM domain.
    • 细胞定位Nucleus. Localizes to nuclear foci and colocalizes with RAD51.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C20orf154 antibody
      • dJ967N21.5 antibody
      • DNA helicase MCM8 antibody
      • DNA replication licensing factor MCM8 antibody
      • MCM8 antibody
      • MCM8_HUMAN antibody
      • MGC119522 antibody
      • MGC119523 antibody
      • MGC12866 antibody
      • MGC4816 antibody
      • Minichromosome maintenance 8 antibody
      • Minichromosome maintenance complex component 8 antibody
      • REC antibody
      see all

    Anti-MCM8 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57829 MCM8 antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa

    Anti-MCM8 antibody (ab57829)参考文献

    ab57829 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57829.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"