Anti-MCL1抗体, prediluted (ab15470)

概述

  • 产品名称Anti-MCL1抗体, prediluted
    参阅全部 MCL1 一抗
  • 描述
    兔多克隆抗体to MCL1, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cat, Dog
  • 免疫原

    Synthetic peptide:

    SPEEELDGYEPEPLGKRPA

    , corresponding to amino acids 121-139 of Human MCL1.

  • 阳性对照
    • Tonsil.

性能

应用

Our Abpromise guarantee covers the use of ab15470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready diluted. For 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
    • 序列相似性Belongs to the Bcl-2 family.
    • 翻译后修饰Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
      Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
      Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
    • 细胞定位Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Bcl 2 related protein EAT/mcl1 antibody
      • Bcl-2-like protein 3 antibody
      • Bcl-2-related protein EAT/mcl1 antibody
      • BCL2 related antibody
      • Bcl2-L-3 antibody
      • BCL2L3 antibody
      • EAT antibody
      • Induced myeloid leukemia cell differentiation protein Mcl 1 antibody
      • Induced myeloid leukemia cell differentiation protein Mcl-1 antibody
      • MCL 1 antibody
      • MCL1 antibody
      • MCL1-ES antibody
      • mcl1/EAT antibody
      • MCL1_HUMAN antibody
      • MCL1L antibody
      • MCL1S antibody
      • MGC104264 antibody
      • MGC1839 antibody
      • Myeloid Cell Leukemia 1 antibody
      • Myeloid cell leukemia ES antibody
      • Myeloid cell leukemia sequence 1 antibody
      • Myeloid cell leukemia sequence 1 BCL2 related antibody
      • Myeloid cell leukemia sequence 1 isoform 1 antibody
      • OTTHUMP00000032794 antibody
      • OTTHUMP00000032795 antibody
      • TM antibody
      see all

    Anti-MCL1 antibody, prediluted 图像

    • ab15470 staining MCL1 in human tonsil by Immunohistochemistry (FFPE-sections).

    Anti-MCL1 antibody, prediluted (ab15470)参考文献

    ab15470 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (Tonsil)
    Specification Tonsil
    Fixative Formaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: EDTA
    Permeabilization No
    Blocking step Serum as blocking agent for 15 minute(s) · Concentration: 20% · Temperature: RT°C
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    提交于 Sep 26 2007

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"