概述

  • 产品名称Anti-MCFD2抗体
    参阅全部 MCFD2 一抗
  • 描述
    小鼠单克隆抗体to MCFD2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-147 of Human MCFD2

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
    • 疾病相关Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2) [MIM:613625]; also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
    • 序列相似性Contains 2 EF-hand domains.
    • 结构域Essentially unstructured in the absence of calcium ions. Requires calcium ions for folding.
    • 细胞定位Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 1810021C21Rik antibody
      • DKFZp686G21263 antibody
      • F5F8D antibody
      • LMAN1IP antibody
      • MCFD 2 antibody
      • Mcfd2 antibody
      • MCFD2_HUMAN antibody
      • Multiple coagulation factor deficiency protein 2 antibody
      • Neural stem cell derived neuronal survival protein antibody
      • Neural stem cell-derived neuronal survival protein antibody
      • SDNSF antibody
      see all

    Anti-MCFD2 antibody 图像

    • MCFD2 antibody (ab57843) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human ovary, clear cell carcinoma.
    • Western blot against tagged recombinant protein immunogen using ab57843 MCFD2 antibody at 1ug/ml. Predicted band size of immunogen is 42 kDa

    Anti-MCFD2 antibody (ab57843)参考文献

    ab57843 has not yet been referenced specifically in any publications.

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