概述

  • 产品名称
  • 描述
    兔多克隆抗体to MCC
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-316 of Human MCC (P23508).

  • 阳性对照
    • IMR32 and U-87 MG whole cell lysates; Human Colon carcinoma tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab125920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
  • 组织特异性
    Expressed in a variety of tissues.
  • 序列相似性
    Belongs to the MCC family.
  • 细胞定位
    Cell membrane. Nucleus. Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Colorectal mutant cancer protein antibody
    • CRCM_HUMAN antibody
    • DKFZp762O1615 antibody
    • FLJ38893 antibody
    • FLJ46755 antibody
    • MCC 1 antibody
    • MCC antibody
    • MCC1 antibody
    • Mutated in colorectal cancers antibody
    • Protein MCC antibody
    see all

图片

  • Anti-MCC antibody (ab125920) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size : 93 kDa
  • ab125920, at 1/250 dilution, staining MCC in Paraffin-embedded Human Colon carcinoma tissue by immunohistochemistry.

文献

ab125920 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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