Mouse, Rat, Cow
Recombinant fragment, corresponding to a region within amino acids 1-316 of Human MCC (P23508).
IMR32 and U-87 MG whole cell lysates; Human Colon carcinoma tissue.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 78% PBS, 20% Glycerol, 1% BSA
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Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 93 kDa.
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Expressed in a variety of tissues.
Belongs to the MCC family.
Cell membrane. Nucleus. Cytoplasm.
Information by UniProt
Colorectal mutant cancer protein antibody
Western blot - Anti-MCC antibody (ab125920)
Anti-MCC antibody (ab125920) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg
Predicted band size: 93 kDa 7.5% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCC antibody (ab125920)
ab125920, at 1/250 dilution, staining MCC in Paraffin-embedded Human Colon carcinoma tissue by immunohistochemistry.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"