概述

  • 产品名称Anti-MCAF1抗体
    参阅全部 MCAF1 一抗
  • 描述
    兔多克隆抗体to MCAF1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 25 and 100 of Human MCAF1 (AAQ92978.1).

  • 阳性对照
    • Human small cell lung cancer. Mouse squamous cell carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性MCAF1 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can act both as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. MCAF1 is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • Activating transcription factor 7 interacting protein 1 antibody
      • ATF interacting protein antibody
      • ATF IP antibody
      • ATF7IP antibody
      • ATFa associated modulator antibody
      • FLJ10139 antibody
      • FLJ10688 antibody
      • hAM antibody
      • HGNC:20092 antibody
      • MBD1 containing chromatin associated factor antibody
      • MCAF 1 antibody
      • MCAF antibody
      • p621 antibody
      see all

    Anti-MCAF1 antibody 图像

    • ab84497, at 1/250 dilution, staining MCAF1 in formalin-fixed, paraffin-embedded human small cell lung cancer by Immunohistochemistry, using DAB staining.
    • ab84497, at 1/250 dilution, staining MCAF1 in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry, using DAB staining.

    Anti-MCAF1 antibody (ab84497)参考文献

    This product has been referenced in:
    • Minkovsky A  et al. The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. Epigenetics Chromatin 7:12 (2014). Mouse . Read more (PubMed: 25028596) »

    See 1 Publication for this product

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