Anti-MCAF1抗体[2052C2a] (ab50956)

概述

  • 产品名称Anti-MCAF1抗体[2052C2a]
    参阅全部 MCAF1 一抗
  • 描述
    小鼠单克隆抗体[2052C2a] to MCAF1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment (Human), amino acids 50-200.

性能

应用

Our Abpromise guarantee covers the use of ab50956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Detects a band of approximately 40 kDa (predicted molecular weight: 136 kDa).

靶标

  • 相关性MCAF1 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can act both as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. MCAF1 is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • Activating transcription factor 7 interacting protein 1 antibody
    • ATF interacting protein antibody
    • ATF IP antibody
    • ATF7IP antibody
    • ATFa associated modulator antibody
    • FLJ10139 antibody
    • FLJ10688 antibody
    • hAM antibody
    • HGNC:20092 antibody
    • MBD1 containing chromatin associated factor antibody
    • MCAF 1 antibody
    • MCAF antibody
    • p621 antibody
    see all

Anti-MCAF1 antibody [2052C2a] 图像

Anti-MCAF1 antibody [2052C2a] (ab50956)参考文献

ab50956 has not yet been referenced specifically in any publications.

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