Anti-MC4 Receptor抗体(ab106596)

概述

  • 产品名称Anti-MC4 Receptor抗体
    参阅全部 MC4 Receptor 一抗
  • 描述
    兔多克隆抗体to MC4 Receptor
  • 经测试应用适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 19 amino acid synthetic peptide near the N terminus of Human MC4 Receptor (NP_005903).

  • 阳性对照
    • Rat brain tissue lysate; Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab106596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 2.5 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 37 kDa.

靶标

  • 功能Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.
  • 组织特异性Brain, placental, and gut tissues.
  • 疾病相关Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MC4-R antibody
    • MC4R antibody
    • MC4R_HUMAN antibody
    • Melanocortin 4 receptor antibody
    • Melanocortin receptor 4 antibody
    • MGC126851 antibody
    • MGC138197 antibody
    see all

Anti-MC4 Receptor antibody 图像

  • All lanes : Anti-MC4 Receptor antibody (ab106596) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat brain tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 37 kDa
  • ab106596, at 2.5 µg/ml, staining MC4 Receptor in Human brain tissue by Immunohistochemistry.
  • Immunofluorescence of MC4R in Human Brain cells using ab106596 at 20 ug/ml.

Anti-MC4 Receptor antibody (ab106596)参考文献

ab106596 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Placenta)
Specification Placenta
Fixative Formaldehyde
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
Permeabilization No
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
Username

Mr. Carl Hobbs

Verified customer

提交于 Sep 06 2012

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (brains 25um sections)
Specification brains 25um sections
Fixative formalin
Permeabilization Yes - 1xPBT
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 17°C
Username

Abcam user community

Verified customer

提交于 Sep 04 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"