概述

  • 产品名称Anti-MBNL2抗体
    参阅全部 MBNL2 一抗
  • 描述
    兔多克隆抗体to MBNL2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 46-95 (ENGRVIACFD SLKGRCSREN CKYLHPPTHL KTQLEINGRN NLIQQKTAAA) of Human MBNL2.

  • 阳性对照
    • Human fetal brain lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab105331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
  • 组织特异性Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 序列相似性Belongs to the muscleblind family.
    Contains 4 C3H1-type zinc fingers.
  • 细胞定位Nucleus. Cytoplasm. Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853).
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp781H1296 antibody
    • MBLL antibody
    • MBLL39 antibody
    • Mbnl2 antibody
    • MBNL2_HUMAN antibody
    • MGC120625 antibody
    • MGC120626 antibody
    • MGC120628 antibody
    • Muscleblind like 2 antibody
    • muscleblind like protein 1 antibody
    • muscleblind like protein 2 antibody
    • muscleblind like protein like 39 antibody
    • muscleblind like splicing regulator 2 antibody
    • Muscleblind-like protein 1 antibody
    • Muscleblind-like protein 2 antibody
    • Muscleblind-like protein-like 39 antibody
    • Muscleblind-like protein-like antibody
    • OTTHUMP00000178763 antibody
    • PRO2032 antibody
    • RP11-128N14.1 antibody
    see all

Anti-MBNL2 antibody 图像



  • Predicted band size : 41 kDa
    Western blot analysis of Human fetal heart tissue lysate labeling MBNL2 with ab105331 at 1.0µg/ml.


  • Predicted band size : 41 kDa
    Western blot analysis of HepG2 cell lysate labeling MBNL2 with ab105331 at 1.0µg/ml.


  • Predicted band size : 41 kDa
    Western blot analysis of HeLa cell lysate labeling MBNL2 with ab105331 at 1.0µg/ml.
  • Anti-MBNL2 antibody (ab105331) at 0.5 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 41 kDa
    Gel concentration: 12%

Anti-MBNL2 antibody (ab105331)参考文献

ab105331 has not yet been referenced specifically in any publications.

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