Anti-MBD5抗体(ab103144)

概述

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab103144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 160 kDa.

靶标

  • 功能
    Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
  • 组织特异性
    Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
  • 疾病相关
    Defects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1) [MIM:156200]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • 序列相似性
    Contains 1 MBD (methyl-CpG-binding) domain.
    Contains 1 PWWP domain.
  • 结构域
    Both MBD and PWWP domains are necessary for chromocentric localization.
  • 细胞定位
    Nucleus. Chromosome. Associated with pericentric heterochromatin and Nucleus. Not associated with pericentric heterochromatin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9430004D19Rik antibody
    • AA536666 antibody
    • AI426407 antibody
    • C030040A15Rik antibody
    • FLJ11113 antibody
    • FLJ30517 antibody
    • KIAA1461 antibody
    • MBD5 antibody
    • MBD5_HUMAN antibody
    • methyl CpG binding domain protein 5 antibody
    • Methyl CpG binding protein MBD5 antibody
    • Methyl-CpG-binding domain protein 5 antibody
    • Methyl-CpG-binding protein MBD5 antibody
    • RP23 167N13.1 antibody
    see all

图片

  • Anti-MBD5 antibody (ab103144) at 5 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 160 kDa
  • Anti-MBD5 antibody (ab103144) at 5 µg/ml + HepG2 cell lysate at 50 µg

    Predicted band size : 160 kDa

实验方案

文献

ab103144 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for contacting Abcam regarding ab103144.


Regarding the immunogen sequence, the antibody was raised against aa623-840 of MBD5. The sequence can be found in UniProt entry Q9P267.

MFPPTANMLLPTGEGQSGRAALRDKLMSQQKDALRKRKQPPT...

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Thank you for bringing this to our attention.

I have forwarded the information about the immunogen for ab103144 to our datasheets team, who are going to look into the matter and make any changes that are need.

Please let me know if ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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