The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
功能Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
组织特异性Highly expressed in brain, heart, kidney, stomach, testis and placenta.
序列相似性Contains 1 MBD (methyl-CpG-binding) domain.
细胞定位Nucleus. Nuclear, in discrete foci. Detected at replication foci in late S phase.