Anti-Maxi Potassium channel alpha抗体(ab104711)

概述

  • 产品名称Anti-Maxi Potassium channel alpha抗体
    参阅全部 Maxi Potassium channel alpha 一抗
  • 描述
    兔多克隆抗体to Maxi Potassium channel alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 641-690 (ESRSRKRILI NPGNHLKIQE GTLGFFIASD AKEVKRAFFY CKACHDDITD) of Human Maxi Potassium channel alpha (NP_001014797).

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab104711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 131 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
  • 组织特异性Widely expressed. Except in myocytes, it is almost ubiquitously expressed.
  • 疾病相关Generalized epilepsy and paroxysmal dyskinesia
  • 序列相似性Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
    Contains 1 RCK N-terminal domain.
  • 结构域The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
    The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
    The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium.
    The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+).
    The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel.
    The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation.
  • 翻译后修饰Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.
    Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • subfamily M subunit alpha-1 antibody
    • BK channel antibody
    • BKCA alpha antibody
    • BKCA alpha subunit antibody
    • BKTM antibody
    • Calcium-activated potassium channel antibody
    • Calcium-activated potassium channel subunit alpha-1 antibody
    • Drosophila slowpoke like antibody
    • hSlo antibody
    • K(VCA)alpha antibody
    • KCa1.1 antibody
    • KCMA1_HUMAN antibody
    • KCNMA antibody
    • KCNMA1 antibody
    • Maxi K channel antibody
    • Maxi Potassium channel alpha antibody
    • MaxiK antibody
    • SAKCA antibody
    • SLO alpha antibody
    • SLO antibody
    • Slo homolog antibody
    • Slo-alpha antibody
    • Slo1 antibody
    • Slowpoke homolog antibody
    see all

Anti-Maxi Potassium channel alpha antibody 图像

  • Anti-Maxi Potassium channel alpha antibody (ab104711) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 131 kDa

Anti-Maxi Potassium channel alpha antibody (ab104711)参考文献

ab104711 has not yet been referenced specifically in any publications.

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