概述

  • 产品名称Anti-MAVS抗体
    参阅全部 MAVS 一抗
  • 描述
    小鼠多克隆抗体to MAVS
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human MAVS protein (AAH44952.1).

  • 阳性对照
    • Human placenta tissue lysate. Cell lysate from transfected 293T cells.

性能

应用

Our Abpromise guarantee covers the use of ab89825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.

靶标

  • 功能Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • 组织特异性Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • 序列相似性Contains 1 CARD domain.
  • 结构域Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • 翻译后修饰Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • 细胞定位Mitochondrion outer membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CARD adapter inducing interferon beta antibody
    • CARD adaptor inducing IFN beta antibody
    • Cardif antibody
    • DKFZp666M015 antibody
    • FLJ27482 antibody
    • FLJ41962 antibody
    • IFN B promoter stimulator 1 antibody
    • Interferon beta promoter stimulator protein 1 antibody
    • Ips 1 antibody
    • IPS-1 antibody
    • Ips1 antibody
    • KIAA1271 antibody
    • MAVS antibody
    • MAVS_HUMAN antibody
    • Mitochondrial anti viral signaling protein antibody
    • Mitochondrial Antiviral Signaling antibody
    • Mitochondrial antiviral signaling protein antibody
    • Mitochondrial antiviral-signaling protein antibody
    • Putative NF kappa B activating protein 031N antibody
    • Putative NF-kappa-B-activating protein 031N antibody
    • Virus induced signaling adapter antibody
    • virus induced signaling adaptor antibody
    • Virus-induced-signaling adapter antibody
    • VISA antibody
    see all

Anti-MAVS antibody 图像

  • Anti-MAVS antibody (ab89825) at 1 µg/ml + Human placenta tissue lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 57 kDa
    Observed band size : ~57 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MAVS antibody (ab89825) at 1 µg/ml

    Lane 1 : cell lysate from MAVS transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.

    Developed using the ECL technique

    Predicted band size : 57 kDa
    Observed band size : ~75 kDa (why is the actual band size different from the predicted?)

Anti-MAVS antibody (ab89825)参考文献

ab89825 has not yet been referenced specifically in any publications.

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