Anti-Matriptase 2抗体- Catalytic domain (ab56182)


  • 产品名称Anti-Matriptase 2抗体- Catalytic domain
    参阅全部 Matriptase 2 一抗
  • 描述
    兔多克隆抗体to Matriptase 2 - Catalytic domain
  • 特异性ab56182 reacts with human Matripase 2 (TMPRSS6), and does not react with the other TMPRSSs. ab56182 recognizes all but the 2 truncated forms of human Matripase 2.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide based on the catalytic domain of Matriptase 2 (Human)



Our Abpromise guarantee covers the use of ab56182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 89 kDa.

    Note: Glycosylation and other posttranslational modifications make matriptase 2 run at higher than expected mass on reduced SDS PAGE gels.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
    • 组织特异性Liver specific.
    • 疾病相关Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
    • 序列相似性Belongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 3 LDL-receptor class A domains.
      Contains 1 peptidase S1 domain.
    • 结构域Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IRIDA antibody
      • Matriptase-2 antibody
      • Membrane bound mosaic serine proteinase matriptase 2 antibody
      • Membrane type serine proteinase 2 antibody
      • MTSP 2 antibody
      • MTSP2 antibody
      • PVAE354 antibody
      • TMPRSS 6 antibody
      • TMPRSS6 antibody
      • TMPS6_HUMAN antibody
      • TMSP 6 antibody
      • TMSP6 antibody
      • Transmembrane protease serine 6 antibody
      • Type II Membrane Serine Proteinase 6 antibody
      see all

    Anti-Matriptase 2 antibody - Catalytic domain 图像

    • All lanes : Anti-Matriptase 2 antibody - Catalytic domain (ab56182) at 1/1000 dilution

      Lane 1 : Cell media from human amnion-derived WISH cells
      Lane 2 : Cell media from human amnion-derived WISH cells

      Predicted band size : 89 kDa

    Anti-Matriptase 2 antibody - Catalytic domain (ab56182)参考文献

    ab56182 has not yet been referenced specifically in any publications.

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