Anti-Matriptase 2抗体(ab106842)

概述

  • 产品名称Anti-Matriptase 2抗体
    参阅全部 Matriptase 2 一抗
  • 描述
    兔多克隆抗体to Matriptase 2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide, corresponding to a region within N-terminal amino acids 71-120 (LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK) of Human Matriptase 2 (NP_705837).

  • 阳性对照
    • Jurkat cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab106842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
  • 组织特异性Liver specific.
  • 疾病相关Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 3 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
  • 结构域Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IRIDA antibody
    • Matriptase-2 antibody
    • Membrane bound mosaic serine proteinase matriptase 2 antibody
    • Membrane type serine proteinase 2 antibody
    • MTSP 2 antibody
    • MTSP2 antibody
    • PVAE354 antibody
    • TMPRSS 6 antibody
    • TMPRSS6 antibody
    • TMPS6_HUMAN antibody
    • TMSP 6 antibody
    • TMSP6 antibody
    • Transmembrane protease serine 6 antibody
    • Type II Membrane Serine Proteinase 6 antibody
    see all

Anti-Matriptase 2 antibody 图像

  • Anti-Matriptase 2 antibody (ab106842) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 90 kDa
    12% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling Matriptase 2 with ab106842 at 5µg/ml.

Anti-Matriptase 2 antibody (ab106842)参考文献

ab106842 has not yet been referenced specifically in any publications.

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