概述

  • 产品名称
    Anti-Matrin 3抗体
    参阅全部 Matrin 3 一抗
  • 描述
    兔多克隆抗体to Matrin 3
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    A region within synthetic peptide: MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA, corresponding to N terminal amino acids 1-50 of Human Matrin 3

  • 阳性对照
    • Jurkat cell lysate, Human heart tissue.

性能

应用

Our Abpromise guarantee covers the use of ab51081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 95 kDa (predicted molecular weight: 95 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

靶标

  • 功能
    May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.
  • 疾病相关
    Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.
  • 序列相似性
    Contains 1 matrin-type zinc finger.
    Contains 2 RRM (RNA recognition motif) domains.
  • 细胞定位
    Nucleus matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALS21 antibody
    • KIAA0723 antibody
    • Matr3 antibody
    • MATR3_HUMAN antibody
    • Matrin-3 antibody
    • Matrin3 antibody
    • MPD2 antibody
    • VCPDM antibody
    • Vocal cord and pharyngeal weakness with distal myopathy antibody
    see all

图片

  • Anti-Matrin 3 antibody (ab51081) at 1.25 µg + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 95 kDa
    Observed band size : 95 kDa
  • Ab51081 at 8µg/ml staining myocardial cells of paraffin embedded human heart tissue.
  • Ab51081 at 8µg/ml staining paraffin embedded human skeletal muscle cells.

文献

This product has been referenced in:
  • Rajgor D  et al. Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies. Mol Biol Cell 27:3894-3902 (2016). WB, ICC/IF ; Human . Read more (PubMed: 27733621) »
  • Depreux FF  et al. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Hum Mol Genet 24:4284-95 (2015). Read more (PubMed: 25948554) »

See all 3 Publications for this product

客户评价及客户问答

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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