概述

  • 产品名称Anti-MAS1抗体
    参阅全部 MAS1 一抗
  • 描述
    兔多克隆抗体to MAS1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: PKYQSALVCA LLWALSCLVT TMEYVMCIDR EEESHSRNDC RAVIIFIAIL, corresponding to a region within internal sequence amino acids 145-194 of Human MAS1

  • 阳性对照
    • HepG2 cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab66030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).Can be blocked with MAS1 peptide (ab150298). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 4 - 8 µg/ml.

靶标

  • 功能Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
  • 疾病相关The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MAS antibody
    • MAS proto oncogene antibody
    • Mas-related G protein-coupled receptor A antibody
    • MAS_HUMAN antibody
    • Mas1 antibody
    • MAS1 oncogene antibody
    • MAS1 proto-oncogene, G protein-coupled receptor antibody
    • MGRA antibody
    • Proto-oncogene Mas antibody
    see all

Anti-MAS1 antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling MAS1 with ab66030 at 4-8µg/ml. Arrows indicate positively labelled epithelial cells of the renal tubule. Magnification: 400X.

  • Anti-MAS1 antibody (ab66030) at 1.25 µg/ml + HepG2 cell lysate at 10 µg with 5% skim milk / PBS buffe

    Secondary
    HRP conjugated anti-Rabbit IgG at 50,000 - 100,000 dilution

    Predicted band size : 37 kDa
    Observed band size : 37 kDa

Anti-MAS1 antibody (ab66030)参考文献

This product has been referenced in:
  • Wong TP  et al. Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport. Am J Physiol Endocrinol Metab 303:E669-81 (2012). WB . Read more (PubMed: 22811473) »
  • Saraiva VB  et al. Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS One 6:e17174 (2011). WB ; Human . Read more (PubMed: 21364758) »

See all 2 Publications for this product

Product Wall

Te voy comentando acerca de lo que hablamos ayer por teléfono.

Como había varias cosas en marcha, te explico por partes:

MAS1 (ab66030):



En referencia a la posibilidad de añadir al cat&aacut...

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Thank you for contacting us.

My Spanish colleague is currently out of the office.

About the ER alpha R andER beta R antibodies:
The antibodies Ariana suggested to you are covered by our Abpromise, which guarantees that the product...

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Gracias por contactarnos.



He llevado a cabo una búsqueda en nuestro catálogo de anticuerpos contra los receptores indicados:



-Para MAS, tenemos dos opciones, pero lamentablemente ninguna de ellas se h...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"