概述

  • 产品名称Anti-MARK2抗体
    参阅全部 MARK2 一抗
  • 描述
    兔多克隆抗体to MARK2
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Ferret, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between amino acids 300 and 350 of Human MARK2 (NP_001034558.2).

  • 阳性对照
    • 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab113267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 88 kDa.
IP Use at 2-10 µg/mg of lysate.

靶标

  • 功能Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
  • 组织特异性High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.
    Contains 1 KA1 (kinase-associated) domain.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • 细胞定位Cell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ELKL motif kinase 1 antibody
    • ELKL motif kinase antibody
    • EMK-1 antibody
    • EMK1 antibody
    • MAP/microtubule affinity regulating kinase 2 antibody
    • MAP/microtubule affinity-regulating kinase 2 antibody
    • Mark2 antibody
    • MARK2_HUMAN antibody
    • MGC99619 antibody
    • PAR 1 antibody
    • Par 1b antibody
    • PAR1 homolog antibody
    • Par1b antibody
    • Ser/Thr protein kinase PAR 1B antibody
    • Serine/threonine protein kinase EMK antibody
    • Serine/threonine protein kinase MARK2 antibody
    • Serine/threonine-protein kinase MARK2 antibody
    see all

Anti-MARK2 antibody 图像

  • 1 mg whole cell lysate from 293T cells was immunoprecipitated using
    Lane 1: ab113267 at 6 µg/mg lysate
    Lane 2: a Rabbit anti-MARK2 antibody that recognizes a downstream epitope
    Lane 3: a control IgG.
    20% of immunoprecipitates was loaded on the gel.
    For WB of immunoprecipitated MARK2, ab113267 was used at 1 µg/ml.
    Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-MARK2 antibody (ab113267)参考文献

ab113267 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113267.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"