概述

  • 产品名称Anti-MARCH9抗体
    参阅全部 MARCH9 一抗
  • 描述
    兔多克隆抗体to MARCH9
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Mouse, Human
  • 免疫原

    A synthetic peptide corresponding to C-terminal residues of human MARCH9

性能

应用

Our Abpromise guarantee covers the use of ab56123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性MARCH9 (membrane-associated RING-CH protein IX) belongs to MARCH family, which contains at least seven membrane-associated RING-CH (MARCH)proteins. All MARCH proteins are ubiquitin ligases and located to subcellular membranes, and several MARCH proteins reduce surface levels of known substrates of the viral K3 family. Two closely related proteins, MARCH-IV and MARCH-IX, reduce surface expression of MHC-I molecules. In the presence of MARCH-IV or MARCH-IX, MHC-I are ubiquitinated and rapidly internalized by endocytosis. The functional similarity of the MARCH family and the K3 family of viral immune evasion proteins suggests that the viral immune evasion proteins were derived from MARCH proteins, a novel family of transmembrane ubiquitin ligases that seems to target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail.
  • 细胞定位Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 数据库链接
  • 别名
    • BC019560 antibody
    • E3 ubiquitin protein ligase MARCH9 antibody
    • FLJ36578 antibody
    • MARCH IX antibody
    • Membrane associated RING CH protein IX antibody
    • membrane associated ring finger (C3HC4) 9 antibody
    • Membrane associated RING finger protein 9 antibody
    • RING finger protein 179 antibody
    • RNF179 antibody
    see all

Anti-MARCH9 antibody (ab56123)参考文献

ab56123 has not yet been referenced specifically in any publications.

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