概述

  • 产品名称
  • 描述
    兔多克隆抗体to MARCH8
  • 经测试应用
    适用于: WB, ELISA, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    A 17 amino acid synthetic peptide from near the C-terminus of Human MARCH8.

  • 阳性对照
    • HeLa cell lysate; Human Placenta and Human Prostate tissue; HeLa cells

性能

应用

Our Abpromise guarantee covers the use of ab109690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 33 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.
ICC Use a concentration of 2.5 µg/ml.

靶标

  • 功能
    E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • 组织特异性
    Broadly expressed. Present in immature dendritic cells (at protein level).
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 RING-CH-type zinc finger.
  • 结构域
    The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 细胞定位
    Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c MIR antibody
    • c-MIR antibody
    • Cellular modulator of immune recognition antibody
    • E3 ubiquitin protein ligase MARCH8 antibody
    • E3 ubiquitin-protein ligase MARCH8 antibody
    • MARCH 8 antibody
    • MARCH VIII antibody
    • MARCH-VIII antibody
    • MARCH8 antibody
    • MARH8_HUMAN antibody
    • Membrane associated RING CH protein VIII antibody
    • Membrane associated ring finger (C3HC4) 8 antibody
    • Membrane associated RING finger protein 8 antibody
    • Membrane-associated RING finger protein 8 antibody
    • Membrane-associated RING-CH protein VIII antibody
    • MIR antibody
    • OTTHUMP00000058921 antibody
    • RING finger protein 178 antibody
    • RNF178 antibody
    see all

图片

  • Lane 1 : Anti-MARCH8 antibody (ab109690) at 0.5 µg/ml
    Lane 2 : Anti-MARCH8 antibody (ab109690) at 1 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate


    Predicted band size : 33 kDa
  • ab109690, at 5 µg/ml, staining MARCH8 in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • ab109690, at 5 µg/ml, staining MARCH8 in formalin-fixed, paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab109690, at 2.5 µg/ml, staining MARCH8 in HeLa cells Immunocytochemistry.

文献

ab109690 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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