概述

  • 产品名称
  • 描述
    兔多克隆抗体to MARCH2
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region of human MARCH2

  • 阳性对照
    • Jurkat cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab76397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:312500.

靶标

  • 功能
    E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
  • 组织特异性
    Broadly expressed.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 RING-CH-type zinc finger.
  • 结构域
    The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 细胞定位
    Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 ubiquitin protein ligase MARCH2 antibody
    • E3 ubiquitin-protein ligase MARCH2 antibody
    • EC 6.3.2.- antibody
    • HSPC240 antibody
    • MARCH 2 antibody
    • MARCH II antibody
    • MARCH-II antibody
    • march2 antibody
    • MARH2_HUMAN antibody
    • Membrane associated RING CH protein II antibody
    • Membrane associated ring finger (C3HC4) 2 antibody
    • Membrane associated RING finger protein 2 antibody
    • Membrane-associated RING finger protein 2 antibody
    • Membrane-associated RING-CH protein II antibody
    • RING finger protein 172 antibody
    • RNF172 antibody
    see all

Anti-MARCH2 antibody 图像

实验方案

Anti-MARCH2 antibody (ab76397)参考文献

This product has been referenced in:
  • Han SO  et al. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound ß(2)-adrenergic receptors. J Cell Biol 199:817-30 (2012). WB . Read more (PubMed: 23166351) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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