概述

  • 产品名称Anti-MARCH2抗体
    参阅全部 MARCH2 一抗
  • 描述
    小鼠多克隆抗体to MARCH2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein (Human)

  • 阳性对照
    • MARCH2 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab68022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 17 kDa (predicted molecular weight: 27 kDa).

靶标

  • 功能E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
  • 组织特异性Broadly expressed.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 RING-CH-type zinc finger.
  • 结构域The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 细胞定位Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 ubiquitin protein ligase MARCH2 antibody
    • E3 ubiquitin-protein ligase MARCH2 antibody
    • EC 6.3.2.- antibody
    • HSPC240 antibody
    • MARCH 2 antibody
    • MARCH II antibody
    • MARCH-II antibody
    • march2 antibody
    • MARH2_HUMAN antibody
    • Membrane associated RING CH protein II antibody
    • Membrane associated ring finger (C3HC4) 2 antibody
    • Membrane associated RING finger protein 2 antibody
    • Membrane-associated RING finger protein 2 antibody
    • Membrane-associated RING-CH protein II antibody
    • RING finger protein 172 antibody
    • RNF172 antibody
    see all

Anti-MARCH2 antibody 图像

  • All lanes : Anti-MARCH2 antibody (ab68022) at 1/500 dilution

    Lane 1 : MARCH2 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 27 kDa
    Observed band size : 17 kDa (why is the actual band size different from the predicted?)

Anti-MARCH2 antibody (ab68022)参考文献

ab68022 has not yet been referenced specifically in any publications.

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