• 产品名称
  • 描述
    兔多克隆抗体to MAP3K8
  • 经测试应用
    适用于: IHC-P, ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthesized non-phosphopeptide derived from human MAP3K8 around the phosphorylation site of threonine 290 (R-G-TP-E-I).

  • 阳性对照
    • Human brain tissue; extracts from 293 cells treated with LPS



Our Abpromise guarantee covers the use of ab51208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
ELISA 1/40000.
WB 1/300 - 1/1000. Predicted molecular weight: 53 kDa.


  • 功能
    Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
  • 组织特异性
    Expressed in several normal tissues and human tumor-derived cell lines.
  • 序列相似性
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 发展阶段
    Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
  • 翻译后修饰
    Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues.
  • 细胞定位
  • Information by UniProt
  • 数据库链接
  • 别名
    • AURA2 antibody
    • c COT antibody
    • Cancer Osaka thyroid oncogene antibody
    • CCOT antibody
    • COT antibody
    • COT proto oncogene serine/threonine protein kinase antibody
    • EST antibody
    • ESTF antibody
    • Ewing sarcoma transformant antibody
    • FLJ10486 antibody
    • M3K8_HUMAN antibody
    • MAP3K 8 antibody
    • MAP3K8 antibody
    • MEKK8 antibody
    • Mitogen activated protein kinase kinase kinase 8 antibody
    • Mitogen-activated protein kinase kinase kinase 8 antibody
    • Proto oncogene cCot antibody
    • Proto-oncogene c-Cot antibody
    • Serine/threonine protein kinase cot antibody
    • Serine/threonine-protein kinase cot antibody
    • TPL 2 antibody
    • TPL-2 antibody
    • TPL2 antibody
    • Tumor progression locus 2 antibody
    see all

Anti-MAP3K8 antibody 图像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab51208, with and without immunising peptide.
  • All lanes : Anti-MAP3K8 antibody (ab51208)

    Lane 1 : 293 cells treated with LPS (100ng/ml, 30min) with no immunizing peptide
    Lane 2 : 293 cells treated with LPS (100ng/ml, 30min) with immunizing peptide

    Predicted band size : 53 kDa
    Observed band size : ~60 kDa (why is the actual band size different from the predicted?)

Anti-MAP3K8 antibody (ab51208)参考文献

ab51208 has not yet been referenced specifically in any publications.

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Thank you for your response and for providing some details.

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