概述

  • 产品名称Anti-MAP1S抗体
    参阅全部 MAP1S 一抗
  • 描述
    小鼠单克隆抗体to MAP1S
  • 经测试应用适用于: WB, ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 929-1027 of Human MAP1S with a proprietary tag (NP_060644).

  • 阳性对照
    • Recombinant Protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa

应用

Our Abpromise guarantee covers the use of ab118111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 112 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
ELISA Use at an assay dependent dilution.
Sandwich ELISA Use a concentration of 10 µg/ml.

靶标

  • 功能Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.
  • 组织特异性Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.
  • 序列相似性Belongs to the MAP1 family.
  • 结构域The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
  • 细胞定位Nucleus. Cytoplasm > cytosol. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BPY2-interacting protein 1 antibody
    • BPY2IP1 antibody
    • C19orf5 antibody
    • FLJ10669 antibody
    • MAP-1S antibody
    • MAP1S antibody
    • MAP1S light chain antibody
    • MAP1S_HUMAN antibody
    • MAP8 antibody
    • MGC133087 antibody
    • microtubule-associated protein 1S antibody
    • Microtubule-associated protein 8 antibody
    • Variable charge Y chromosome 2-interacting protein 1 antibody
    • VCY2-interacting protein 1 antibody
    • VCY2IP-1 antibody
    • VCY2IP1 antibody
    see all

Anti-MAP1S antibody 图像

  • Anti-MAP1S antibody (ab118111) at 5 µg/ml + recombinant immunogen at 0.2 µg
    Developed using the ECL technique

    Predicted band size : 112 kDa
  • ab118111 at 10 µg/ml as a capture antibody. The detection limit for recombinant tagged MAP1S is 0.1 ng/ml.

Anti-MAP1S antibody (ab118111)参考文献

ab118111 has not yet been referenced specifically in any publications.

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