Anti-MAP 2a + 2b + 2c抗体[0.N.395] (ab33580)

概述

  • 产品名称Anti-MAP 2a + 2b + 2c抗体[0.N.395]
    参阅全部 MAP 2a + 2b + 2c 一抗
  • 描述
    小鼠单克隆抗体[0.N.395] to MAP 2a + 2b + 2c
  • 特异性Ab33580 is highly specific to MAP 2a, b and c expressed in dendrites and cell bodies of neurons. It recognizes MAP2a and MAP2b (~280kD doublet) and MAP2c (70kD). It shows no crossreactivity with other MAPs, tau and tubulin.
  • 经测试应用适用于: IHC-P, IHC-FoFr, WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Cow, Human, Xenopus laevis, Quail
  • 免疫原

    Full length native protein: Bovine brain MAP2.

  • 表位Ab33580 reacts with an epitope located in in the first 151 amino acids of MAP2.
  • 阳性对照
    • IMR5 or T98G human glioblastoma cells or brain.

性能

应用

Our Abpromise guarantee covers the use of ab33580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-FoFr Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval before commencing the IHC protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 199 kDa.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
  • 序列相似性Contains 3 Tau/MAP repeats.
  • 翻译后修饰Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Isoform MAP2c is phosphorylated by FYN at Tyr-67.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MAP 2 antibody
    • MAP-2 antibody
    • MAP2 antibody
    • MAP2_HUMAN antibody
    • MAP2A antibody
    • MAP2B antibody
    • MAP2C antibody
    • MAP2R antibody
    • Microtubule associated protein 2 antibody
    • Microtubule-associated protein 2 antibody
    • Mtap2 antibody
    see all

Anti-MAP 2a + 2b + 2c antibody [0.N.395] (ab33580)参考文献

ab33580 has not yet been referenced specifically in any publications.

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