Anti-Mannan Binding Lectin/MBL抗体[3B6] (ab23457)
Key features and details
- Mouse monoclonal [3B6] to Mannan Binding Lectin/MBL
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Mannan Binding Lectin/MBL抗体[3B6]
参阅全部 Mannan Binding Lectin/MBL 一抗 -
描述
小鼠单克隆抗体[3B6] to Mannan Binding Lectin/MBL -
宿主
Mouse -
特异性
ab23457 is specific for MBL from human serum or plasma. In Western blotting, ab121075 reacts with Human MBL in both its oligomerized state. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human Mannan Binding Lectin/MBL. Human MBL purified from Human donor plasma.
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表位
The epitope is on the head-neck region of the MBL protein chain. -
阳性对照
- Human liver, Human cancerous liver and Human brain tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
3B6 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23457于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (2) |
1/250.
|
说明 |
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IHC-P
1/250. |
靶标
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功能
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. -
组织特异性
Plasma protein produced mainly in the liver. -
疾病相关
Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections. -
序列相似性
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 4153 Human
- Omim: 154545 Human
- SwissProt: P11226 Human
- Unigene: 499674 Human
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别名
- COLEC 1 antibody
- COLEC1 antibody
- Collectin-1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (17)
ab23457 被引用在 17 文献中.
- Jiao Y et al. Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology. J Diabetes Investig 13:839-849 (2022). PubMed: 34932275
- Jiang S et al. Activation of Complement Pathways in Kidney Tissue May Mediate Tubulointerstitial Injury in Diabetic Nephropathy. Front Med (Lausanne) 9:845679 (2022). PubMed: 35479942
- Liu Y et al. MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis. J Inflamm Res 15:4315-4329 (2022). PubMed: 35923908
- Haddad G et al. Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. J Clin Invest 131:N/A (2021). PubMed: 33351779
- Yadav AK et al. Differential expression of collectins in human placenta and role in inflammation during spontaneous labor. PLoS One 9:e108815 (2014). WB ; Human . PubMed: 25303045