概述

  • 产品名称Anti-MAML1抗体
    参阅全部 MAML1 一抗
  • 描述
    兔多克隆抗体to MAML1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region between residues 75 and 125 of Human MAML1 (NP_055572.1).

  • 阳性对照
    • Breast or ovarian carcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab90654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Antigen retrieval with tris-EDTA pH9.0 buffer recommended.
    Nore: likely to work also with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
    • 组织特异性Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
    • 序列相似性Belongs to the mastermind family.
    • 结构域The C-terminal region is required for transcriptional activation.
    • 细胞定位Nucleus speckle. Nuclear, in a punctate manner.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Mam-1 antibody
      • Mam1 antibody
      • MAML 1 antibody
      • Maml1 antibody
      • MAML1_HUMAN antibody
      • Mastermind like 1 antibody
      • Mastermind-like protein 1 antibody
      see all

    Anti-MAML1 antibody 图像

    • Immunohistochemical detection of Human MAML1 in formalin-fixed parafin-embedded Human ovarian carcinoma tissue using ab90654 at a dilution of 1/250 (DAB staining).

    Anti-MAML1 antibody (ab90654)参考文献

    ab90654 has not yet been referenced specifically in any publications.

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