Anti-MAML1抗体(ab70488)
Key features and details
- Rabbit polyclonal to MAML1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MAML1抗体
参阅全部 MAML1 一抗 -
描述
兔多克隆抗体to MAML1 -
宿主
Rabbit -
特异性
We have data to indicate that this antibody may not cross react with Mouse. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Chimpanzee -
免疫原
Synthetic peptide, corresponding to a region between amino acids 75-125 of Human MAML1
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阳性对照
- Whole cell lysate from HeLa cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab70488于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 108 kDa.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 108 kDa. |
靶标
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功能
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. -
组织特异性
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. -
序列相似性
Belongs to the mastermind family. -
结构域
The C-terminal region is required for transcriptional activation. -
细胞定位
Nucleus speckle. Nuclear, in a punctate manner. - Information by UniProt
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数据库链接
- Entrez Gene: 9794 Human
- Omim: 605424 Human
- SwissProt: Q92585 Human
- Unigene: 631951 Human
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别名
- Mam-1 antibody
- Mam1 antibody
- MAML 1 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab70488 尚未被引用在任何文献中。