功能Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
组织特异性Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
序列相似性Belongs to the mastermind family.
结构域The C-terminal region is required for transcriptional activation.
细胞定位Nucleus speckle. Nuclear, in a punctate manner.