Anti-Malondialdehyde抗体(ab27644)

概述

  • 产品名称Anti-Malondialdehyde抗体
    参阅全部 Malondialdehyde 一抗
  • 描述
    山羊多克隆抗体to Malondialdehyde
  • 特异性This antibody specifically binds to Malondialdehyde LDL and other MDA modified proteins.
  • 经测试应用适用于: ELISA, WB, Conjugationmore details
  • 免疫原

    Chemical/ Small Molecule MDA modified protein

性能

应用

Our Abpromise guarantee covers the use of ab27644 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/2500 - 1/20000.
WB 1/2500 - 1/20000.
Conjugation Use at an assay dependent dilution.

靶标

  • 相关性Malondialdehyde (MDA) is a natural product formed in all mammalian cells as a product of lipid peroxidation. MDA is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. It reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine. The major adduct to DNA is a pyrimidopurinone called M1G which appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors. MDA modified proteins may show altered physico chemical behavior and antigenicity. MDA is toxic and has been implicated in aging mutagenesis, carcinogenesis, diabetic nephropathy and radiation damage. Increased expression of MDA has been reported in the brains of Alzheimer's patients. Antibodies to MDA will help to visualize the MDA adducts.
  • 别名
    • 1133 Tetramethoxypropane antibody
    • MDA antibody

Anti-Malondialdehyde antibody (ab27644)参考文献

ab27644 has not yet been referenced specifically in any publications.

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